Access to appropriate and reliable innovations is essential to the improvement of public health in low-income settings and more broadly, reaching the Sustainable Development Goals (SDGs). Lessons from the Millennium Development Goals era have shown that an integrated approach is needed to implement and reach the SDGs, but it remains difficult to achieve as many sectors and interventions still operate in “silos”. Innovations can be the key to interconnectedness in public health, linking ways to identify disease, rolling out effective vaccination strategies, designing treatment plans, monitoring the effectiveness of interventions, and understanding drug resistance.